Epieriocalyxin A

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Epieriocalyxin A 可以抑制 Caco-2 结肠癌细胞的生长。它可能是未来治疗结肠癌的潜在化合物。

Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.(In Vitro):Epieriocalyxin A (EpiA), a diterpenoid isolated from I. eriocalyx, suppressed Caco-2 colon cancer cell growth. EpiA induced annexin V flipping in the cell membrane and DNA fragment. We also showed that EpiA induced the generation of ROS in cells, as well as damage of the mitochondrial membrane. Western blot results showed that both JNK and ERK1/2 activation was decreased after EpiA treatment in a dose-dependent manner. EpiA increased the expression of caspase 3 and Bax and decreased Bcl2 expression.

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Apoptosis

PERK

ERK

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191545-24-1

344.4

C20H24O5

>98% (HPLC)

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O=C[C@@H]1C(C)(C)C=CC([C@](CO2)1[C@@](CC[C@@](C3)([H])[C@@H](C)C4=O)([H])[C@]43C2=O)=O

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(-20℃)

With Ice Pack

≥ 2 years